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Old 04-30-2011, 12:15 AM   #1
fhhuo6059
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Default 为什么精索静脉曲张可造成男性不育

精索静脉曲张在青年男性中的发病率较高,据1971年的报道,健尔马足疗机三代,在1072名6~19岁的在校学生中,体检发现,188名6~9岁的少年均无精索静脉曲张,而831名1 0~19岁的青少年中有136人有左侧精索静脉曲张,占16.12%。而且,精索静脉曲张引起的不育也不少 见,早在1880年,英国的一位外科医生就首先提出,精索静脉曲张可造成男性不育,但引起不育的机理至今尚 未完全弄清,可能与下列因素有关:

(1)阴囊温度升高 精索静脉曲张后,由于精索静脉内血流郁滞, 可引起阴囊内温度升高,平均高于正常0.6℃,从而影响精子生成。

(2)营养障碍 由于静脉血流郁滞,睾丸、附睾的血液循环受到影响, 其所需的营养和氧气供应缺乏,从而影响了精子发生。

(3)睾丸内分泌功能障碍 由于阴囊内局部温度升高、睾丸的供血和供氧不足,必然影响了睾丸曲细精管内间质 细胞的内分泌功能,从而干扰了精子发生。

(4)毒素作用 由于精索静脉与睾丸静脉之间有丰富的侧支循环, 当发生精索静脉曲张后,引起血液逆流,可将左肾上腺及左肾静脉血中携带的高浓度的毒性代谢产物,如类固醇、 儿茶酚胺、5-羟色胺及前列腺素等, 在未解毒前即流入双侧睾丸,使精子生成受影响,造成不同程度的精子过少、形态异常、运动障碍等 。

(5)氧自由基的破坏作用 一些研究表明,当发生精索静脉曲张时, 睾丸组织内氧自由基增加,脂质过氧化作用加重,从而影响了精子的发生及精子功能。

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