Monoclonal Antibody to Dnmt3a (Clone 64B814. 1)
Methylation of DNA at cytosine residuesplays an important role in regulation of gene expression, genomicimprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes orhypomethylation of bulk genomic DNA may be linked with development ofcancer. To date,
ferragamo ties, 3 families of mammalian DNAmethyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferatingcells and inactivation of this gene causes global demethylation ofgenomic DNA and embryonic lethality. Dnmt2 is expressed at low levels inadult tissues and its inactivation does not affect DNA methylation ormaintenance of methylation. The Dnmt3 family members, Dnmt3a andDnmt3b, are strongly expressed in ES cells but their expression isdown regulated in differentiating ES cells and is low in adultsomatic tissue. Recently, it has been shown that naturally occurringmutations of Dnmt3b gene occurs in patients with a rare autosomalrecessive disorder,
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