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Norcantharidin acid and chitosan salt and anti-tumor activity; rubber chemical constituents of the gyro and the role of anti-TB


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[Chinese Abstract] Chapter Norcantharidin acid and chitosan salt and anti-tumor activity research purposes Norcantharidin acid and alkaline to chitosan salt can reduce the toxicity of cantharidin enhance anti-tumor activity. Alkaline hydrolysis method of intermittent high degree of deacetylation of chitosan and Norcantharidin acid salt was prepared by the acid-base reactions, through mouse tail vein, fed, respectively, for observation into the salt to Norcantharidin acute toxicity to calculate median lethal dose; established tumors in mice transplanted H22 hepatoma models were prepared salt of transplanted H22 liver tumor growth inhibition. The results Norcantharidin acid and chitosan can reduce the salt to go into a cantharidin toxicity; salt low, medium and high dose groups were inhibited tumor growth in mice, inhibition rates were 26.60%, 31.69 %, 44.38%, dose-effect relationship. Conclusion Norcantharidin acid and chitosan salt are added into a water-soluble, reduced toxicity, improved anti-tumor effect. Chapter chemical constituents of the plastic top and plastic anti-TB effect of the ascomycete subphylum gyro gyro glue the fruiting bodies of widely distributed in northern temperate regions in the country located in Jilin, Hebei,Salvatore Ferragamo outlet, Gansu, Sichuan and Yunnan provinces, research found plastic top on H22 liver cancer, U14 cervical cancer, S180 sarcoma and Ehrlich ascites tumor cells significantly inhibited such,MBTシューズ 販売店, and can significantly reduce blood stasis state move ...
[English Abstract] Aim: To prepare the dicarboxylic acid of norcantharidin / chitosan salt,Beats By Dre Studio, in order to reduce the toxicity of norcantharidin and enhance its anti-tumor activity. Methods: The chitosan samples with high degree of deacetylation, low molecular weight were prepared by an intermittent alkaline hydrolysis and H2O2 degradation ,Beats By Dre Headphones, the dicarboxylic acid of norcantharidin was prepared by the hydrolysis. Subsequently, the negatively charged dicarboxylic acid of norcantharidin at acidic pH values ​​allowed the formation ...
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