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chromosome: eight; Location: 8 D3; 8 55.0 cM
See Hp in MapViewer
Chromosome 8 - NC_000074.5
Go to nucleotideGraphics FASTA GenBank
A high-resolution anatomical atlas of the transcriptome within the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan eighteen. PMID 21267068.Mechanisms regulating repression of haptoglobin production by peroxisome proliferator-activated receptor-gamma ligands in adipocytes. Vernochet C, et al. Endocrinology, 2010 Feb. PMID 19952271.Haptoglobin deficiency facilitates the improvement of autoimmune irritation. Galicia G, et al. Eur J Immunol, 2009 Dec. PMID 19795414.The haptoglobin 2-2 genotype is connected with improved redox active hemoglobin derived iron inside the atherosclerotic plaque. Kalet-Litman S, et al. Atherosclerosis,
Office 2007 Serial, 2010 Mar. PMID 19775690.Haptoglobin genotype can be a determinant of survival and cardiac remodeling right after myocardial infarction in diabetic mice. Asaf R,
Office Home And Business 2010 Key, et al. Cardiovasc Diabetol, 2009 Jun two. PMID 19490627.
See all (64) citations in PubMed
Supplied by MGI
Function Proof Code Pubs catalytic activity IEA hemoglobin binding ISO protein homodimerization exercise ISO serine-type endopeptidase activity IEA Procedure Proof Code Pubs liver advancement ISO negative regulation of hydrogen peroxide catabolic method ISO damaging regulation of oxidoreductase activity ISO positive regulation of cell demise ISO proteolysis IEA response to hydrogen peroxide ISO Part Evidence Code Pubs Golgi apparatus ISO endoplasmic reticulum ISO extracellular region IEA extracellular area ISO haptoglobin-hemoglobin complex ISO RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently in the genome annotation cycle, so their variations may possibly not match the RefSeq variations inside the existing genome construct. Recognize version mismatches by evaluating the version from the RefSeq during this segment towards the 1 reported in Genomic regions, transcripts, and merchandise previously mentioned.
mRNA and Protein(s)
NM_017370.2 → NP_059066.1 haptoglobin precursor
Status: VALIDATED
Supply sequence(s) AC125162, AK152698, M96827 Consensus CDS CCDS40470.1 UniProtKB/TrEMBL Q3UBS3 UniProtKB/Swiss-Prot Q61646 Related Ensembl ENSMUSP, ENSMUST Conserved Domains (1) summary cd00190
Location:103 – 343
Blast Score: 430 Tryp_SPc; Trypsin-like serine protease; Many of they are synthesized as inactive precursor zymogens which might be cleaved for the duration of constrained proteolysis to make their lively kinds. Alignment includes also inactive enzymes which have substitutions with the catalytic... RefSeqs of Annotated Genomes: Create 37.2
The subsequent sections include reference sequences that belong to a particular genome build. Explain
This segment consists of genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, these as RefSeqs for chromosomes and scaffolds (contigs) from the two reference and alternate assemblies. Model RNAs and proteins are also reported here.
MGSCv37 C57BL/6J Genomic
NC_000074.5
Range 112099028..112103072, complement Download GenBank,
Windows 7 Serial, FASTA, Sequence Viewer (Graphics)
NT_078575.6
Array 36932382..36936426,
Office 2007 Professional Plus, complement Download GenBank, FASTA, Sequence Viewer (Graphics) Alternate assembly Mm_Celera Genomic
AC_000030.1
Variety 113800405..113804474, complement Download GenBank, FASTA, Sequence Viewer (Graphics)
NW_001030904.1
Range 37576650..37580719, complement Download GenBank,
Office 2010 Home And Business, FASTA, Sequence Viewer (Graphics)